Acute infectious purpura fulminans: pathogenesis and medical management.

  title={Acute infectious purpura fulminans: pathogenesis and medical management.},
  author={G L Darmstadt},
  journal={Pediatric dermatology},
  volume={15 3},
Purpura fulminans (PF) is a potentially disabling and life-threatening disorder characterized by acute onset of progressive cutaneous hemorrhage and necrosis, and disseminated intravascular necrosis. Acute infectious PF occurs most commonly in the setting of meningococcemia due to elaboration of endotoxin. Presence of purpura, particularly when generalized, is an important predictor of a poor outcome following meningococcal infection. Histopathologic hallmarks of acute infectious PF are dermal… CONTINUE READING
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