Acute induction of human IL-8 production by intestinal epithelium triggers neutrophil infiltration without mucosal injury.

@article{Kucharzik2005AcuteIO,
  title={Acute induction of human IL-8 production by intestinal epithelium triggers neutrophil infiltration without mucosal injury.},
  author={Torsten Kucharzik and James T Hudson and Andreas Luegering and Jonathan A. Abbas and Matt Bettini and Jason G Lake and Mary E. Evans and Thomas R. Ziegler and Didier Merlin and James L. Madara and Ifor R Williams},
  journal={Gut},
  year={2005},
  volume={54 11},
  pages={
          1565-72
        }
}
AIM Neutrophil migration in the intestine depends on chemotaxis of neutrophils to CXC chemokines produced by epithelial cells. The goal of this project was to determine if acute induction of a CXC chemokine gradient originating from intestinal epithelial cells is sufficient to induce neutrophil influx into intact intestinal tissue. METHODS AND RESULTS The authors developed a double transgenic mouse model with doxycycline induced human IL-8 expression restricted to intestinal epithelial cells… CONTINUE READING
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