Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors

@inproceedings{Bhattacharyya2017AcuteIO,
  title={Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors},
  author={Sagnik Bhattacharyya and Alice Egerton and Euitae Kim and Lula Rosso and Daniela A Ria{\~n}o Barros and Alexander Hammers and M. F. Brammer and Federico E. Turkheimer and Oliver D. Howes and Philip K. McGuire},
  booktitle={Scientific Reports},
  year={2017}
}
Use of Cannabis, the most widely used illicit drug worldwide, is associated with acute anxiety, and anxiety disorders following regular use. The precise neural and receptor basis of these effects have not been tested in man. Employing a combination of functional MRI (fMRI) and positron emission tomography (PET), we investigated whether the effects of delta-9-tetrahydrocannabinol (delta-9-THC), the main psychoactive ingredient of cannabis, on anxiety and on amygdala response while processing… CONTINUE READING
BETA
12
Twitter Mentions

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 92 REFERENCES

First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430.

  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2016

Test-retest reproducibility and head-to-head comparison with the antagonist [(18)F]altanserin

Ettrup, A. et al. Serotonin 2A receptor agonist binding in th Cimbi-36
  • NeuroImage 130, 167–174, https://doi.org/10.1016/j. neuroimage.2016.02.001
  • 2016

Changes in cerebral CB1 receptor availability after acute and chronic alcohol abuse and monitored abstinence.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2014

Serotonin 2A receptor agonist binding in the human brain with [¹¹C]Cimbi-36.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2014

In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors

T Tsujikawa
  • NeuroImage 84,
  • 2013