Acute hypoxia decreases plasma VEGF concentration in healthy humans.

  title={Acute hypoxia decreases plasma VEGF concentration in healthy humans.},
  author={Kerstin M. Oltmanns and Hartmut Gehring and Sebastian Rudolf and Bernd Schultes and Claudia Hackenberg and Ulrich Schweiger and Jan Born and Horst Lorenz Fehm and Achim Peters},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={290 3},
Vascular endothelial growth factor (VEGF) is known to be upregulated by hypoxia in vitro. However, in vivo data about VEGF regulation in chronic hypoxic diseases are conflicting. We investigated the effects of hypoxia on plasma VEGF concentration in healthy subjects. To control known confounders, such as insulin, glucose concentrations, or exercise, hypoxic effects on VEGF were studied during experimentally clamping glucose concentrations at rest. In a double-blind crossover study design, we… 

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