Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans.

  title={Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans.},
  author={Gesche J{\"u}rgens and Hanne Rolighed Christensen and Kim Br\osen and Jesper Sonne and Steffen Loft and Niels Vidiendal Olsen},
  journal={Clinical pharmacology and therapeutics},
  volume={71 4},
OBJECTIVE Our objective was to investigate the effect of acute hypoxia on the activity of hepatic cytochrome P450 (CYP) enzymes. METHODS Twelve healthy subjects who lived at sea level were exposed to altitude-induced hypoxia for 7 days at 4559 m above sea level. Hepatic CYP enzyme activity was measured before departure, at 24 and 96 hours after arrival to high-altitude location, and at 1 month after return to sea level. CYP enzyme activities were measured by means of the metabolic ratios of… CONTINUE READING

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