Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic).

@article{Aoki1982AcuteHH,
  title={Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic).},
  author={Kozo Aoki and Kazuo Sato},
  journal={Arzneimittel-Forschung},
  year={1982},
  volume={32 9},
  pages={1141-5}
}
The acute effects of oral administration of niludipine (Bay a 7168), a new dihydropyridine derivative Ca2+-antagonist, on blood pressure (BP), hemodynamics and plasma renin activity (PRA) were investigated in patients with essential hypertension (n = 28) and normotensive volunteers (n = 7). In the hypertensives, BP was acutely lowered by 20 mg of niludipine (from 163/94 to 141/83 nmHg at 2 h, n = 7), 40 mg (163/101 to 140/90), and 60 mg (173/106 to 135/85). Niludipine (60 mg) increased cardiac… CONTINUE READING