Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans.

@article{Rana2011AcuteHD,
  title={Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans.},
  author={Omar A Rana and Christopher D Byrne and David Kerr and David V. Coppini and Soha Zouwail and Roxy Senior and Joe Begley and Jeremy J Walker and Kim Greaves},
  journal={Circulation},
  year={2011},
  volume={124 14},
  pages={1548-56}
}
BACKGROUND Hypoglycemia is associated with increased cardiovascular mortality, but the reason for this association is poorly understood. We tested the hypothesis that the myocardial blood flow reserve (MBFR) is decreased during hypoglycemia using myocardial contrast echocardiography in patients with type 1 diabetes mellitus (DM) and in healthy control subjects. METHODS AND RESULTS Twenty-eight volunteers with DM and 19 control subjects underwent hyperinsulinemic clamps with maintained… CONTINUE READING

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