Acute hypertension in a nonhuman primate: humoral and hemodynamic mechanisms.

  title={Acute hypertension in a nonhuman primate: humoral and hemodynamic mechanisms.},
  author={Robert J. Cody and R F Rodger and Loren Howard Hartley and John Burton and J. Alan Herd},
  volume={4 2},
The present study assessed the contribution of the renin-angiotensin system (RAS), dietary sodium, and cardiac output (CO) to the genesis of primate hypertensin in a one-kidney model which was developed to test species-specific renin inhibitors. Reduction of renal perfusion pressure increased mean arterial pressure (MAP) from 105 +/- 4 to 127 +/- 3 mm Hg (p less than 0.0005), associated with increased plasma renin activity (PRA) from 4.9 +/- 0.7 to 13.8 +/- 1.1 ng. (p less than 0.0005… CONTINUE READING
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