Acute hypertension after nitric oxide synthase inhibition is mediated primarily by increased endothelin vasoconstriction.

@article{Banting1996AcuteHA,
  title={Acute hypertension after nitric oxide synthase inhibition is mediated primarily by increased endothelin vasoconstriction.},
  author={J D Banting and Peter Friberg and M A Adams},
  journal={Journal of hypertension},
  year={1996},
  volume={14 8},
  pages={975-81}
}
OBJECTIVE To determine the quantitative roles played by the different vasoconstrictor systems in the acute pressor response in conscious rats before and after inhibition of nitric oxide synthase with Nw-nitro-L-arginine methyl ester (L-NAME). METHODS In conscious male Sprague-Dawley rats, previously instrumented with aortic and venous catheters, the contributions of the different systems were assessed by maximal cumulative pharmacological blockade of alpha 1-adrenoceptors (1 mg/kg prazosin… CONTINUE READING

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