Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model.

@article{BrixChristensen2004AcuteHR,
  title={Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model.},
  author={Vibeke Brix-Christensen and S\oren Kaeseler Andersen and Ren{\'e} Frydensbjerg Andersen and Annette Mengel and Thomas Dyhr and Niels Trolle Andersen and Anders Larsson and Ole Schmitz and Hans \Orskov and Else T\onnesen},
  journal={Anesthesiology},
  year={2004},
  volume={100 4},
  pages={861-70}
}
BACKGROUND Intensive insulin therapy in critically ill patients reduces morbidity and mortality. The current study elucidates whether acute hyperinsulinemia per se could attenuate the systemic cytokine response and improve neutrophil function during endotoxin (lipopolysaccharide)-induced systemic inflammation in a porcine model. METHODS Pigs were anesthetized, mechanically ventilated, randomized into four groups, and followed for 570 min: group 1 (anesthesia solely, n = 10), group 2… CONTINUE READING
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