Acute high dose arteether toxicity in rats.

  title={Acute high dose arteether toxicity in rats.},
  author={Raymond F. Genovese and Donald B. Newman and Karen Ann Gordon and Teresa Brewer},
  volume={20 5},
Acute high dose administration of the artemisinin antimalarial, beta-arteether (AE), was evaluated in rats using an auditory discrimination task (ADT) and histology. After rats were trained on the ADT, AE (25, 75, 125 mg/kg, i.m.) or vehicle (sesame oil) was administered and behavioral performance was evaluated for 11 consecutive days. Histological evaluation of the brains was performed using thionine and cupric-silver staining. Damaged cells were counted in specific brainstem nuclei of all… CONTINUE READING