Acute hepatitis C

  title={Acute hepatitis C},
  author={Anurag Maheshwari and Stuart C. Ray and Paul J. Thuluvath},
  journal={The Lancet},

Acute Hepatitis C

Treatment of acute HCV is now based on a combination of direct-acting antivirals (DAAs) and it seems promising even if clear recommendations regarding optimal regimen and treatment duration are currently unavailable.

[Symptomatic acute hepatitis C: the importance of diagnosis].

Four cases of acute HCV infection are presented and spontaneous viral clearance in two patients at week 12 of follow-up, and sustained virological response was eventually achieved after peginterferon alpha2a monotherapy.

Difficulty of acute hepatitis C diagnosis in a hospitalised patient

A 71-year-old woman developed acute hepatitis while hospitalised for back pain; owing to a positive result, she was diagnosed with acute hepatitis C and several months thereafter, the HCV spontaneously cleared.

Management of Chronic Hepatitis C Virus Infection: Current Perspectives

H hepatitis C virus infection leads to hepatic inflammation, steatosis, cirrhosis, and greater risk of hepatocellular carcinoma, and clinical manifestations include acute infection, chronic infection, non-hepatic complications, and occult infection.

Acute Hepatitis C in an HIV-Infected patient: A Case Report and Review of Literature

This case illustrates the importance of considering acute hepatitis C as a cause of acute hepatitis in HIV-infected men who have sex with men with a recurrent bout of symptoms with an elevation of his alanine aminotransferase and hepatitis C viral levels that promoted anti-hepatitis C virus treatment.

Molecular Detection and Characterization of Hepatitis C Virus

Important concepts in regard to testing for acute HCV infection are that (i) serology and RNA assessment should both be performed and (ii) testing should be undertaken at multiple time points before exclusion of the diagnosis.

Hepatitis C virus: Screening, diagnosis, and interpretation of laboratory assays

This review aims to help blood bank staff regarding options for diagnosis and management of donors positive for HCV and how to establish or exclude a diagnosis of HCV infection and to interpret the tests correctly.

Hepatitis Viruses: Hepatitis C

Unless a vaccine becomes available, prevention of HCV acquisition depends on minimizing exposure by eliminating transfusion of infected blood products, reducing high-risk behaviors, and optimizing infection control practices.

Hepatitis C Virus

  • A. Kim
  • Medicine
    Annals of Internal Medicine
  • 2016
The advent of novel therapies has transformed the approach to patients with hepatitis C virus (HCV) infection, and such cosmetic procedures as tattooing and piercing are considered extremely low risk for HCV transmission as long as strict infection control measures are followed.



Prospective evaluation of community-acquired acute-phase hepatitis C virus infection.

  • A. CoxD. Netski David L. Thomas
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
The data underscore the importance of nucleic acid screening of blood donations to prevent HCV transmission and of long-term follow-up to ascertain whether there is viral persistence, at least among injection drug users.

Hepatitis C: the clinical spectrum of the disease.

High rate of spontaneous clearance of acute hepatitis C virus genotype 3 infection

Not to treat acute hepatitis C genotype 3 infection early but rather to wait at least 3 months after the onset of symptoms when chronicity becomes likely, and to identify patients prior to therapy who have a higher or lower risk for developing a chronic course to avoid unnecessary treatment.

Hepatitis C in asymptomatic blood donors

Although the majority of HCV carriers had both biochemical and histological evidence of chronic viral hepatitis, the extent of liver injury was generally mild and the frequency of severe morbidity or mortality related to HCV infection was less than 10% during the first two decades of infection.

The natural history of hepatitis C virus infection: host, viral, and environmental factors.

The results indicate that although HCV infection can be self-limited or associated with ESLD, the majority of adults have persistent viremia without clinically demonstrable liver disease.

Epidemiology of hepatitis C virus infection in Australia.

Treatment of acute hepatitis C with interferon alfa-2b.

Treatment of acute hepatitis C with interferon alfa-2b with treatment during the acute phase could prevent the development of chronic infection.

Spontaneous viral clearance in patients with acute hepatitis C can be predicted by repeated measurements of serum viral load

Patients with acute icteric hepatitis C have a high rate of spontaneous viral clearance within the first month after the onset of symptoms, and IFN therapy appears only needed in patients who fail to clear the virus within 35 days after onset of Symptoms.

Prevention of spread of hepatitis C

The primary prevention of illegal drug injecting will eliminate the greatest risk factor for HCV infection in the United States and other prevention strategies that need to be widely implemented include risk reduction counseling and services and review and improvement of infection control practices in all types of health care settings.