Acute hepatic failure in India: A perspective from the East

  title={Acute hepatic failure in India: A perspective from the East},
  author={Subrat kumar Acharya and Subrat Kumar Panda and Alka Saxena and S. Datta Gupta},
  journal={Journal of Gastroenterology and Hepatology},
Acute hepatic failure (AHF) in India almost always presents with encephalopathy within 4 weeks of the onset of acute hepatitis. Further subclassification of AHF into hyperacute, acute and subacute forms may not be necessary in this geographical area, where the rapidity of onset of encephalopathy does not seem to influence survival. Viral hepatitis is the cause in approximately 95–100% of patients, who therefore constitute a more homogeneous population than AHF patients in the West. In India… 

Etiopathogenesis of acute hepatic failure: Eastern versus Western countries

Abstract  Etiopathogenesis of acute hepatic failure (AHF) in Eastern and Western countries is distinct. In the East hepatitis viruses cause AHF in more than 95% of such cases, while causes of AHF in

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A decrease in ALF incidence and a changing in its aetiology were observed in Campania during 1992-2018, likely mainly due to 1991 introduction of HBV universal vaccination and may be considered generalizable nationwide.



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One of the largest series of cases of acute failure, managed on a simple intensive supportive therapeutic regimen, yielded results comparable to those reported by centers using a variety of complex therapeutic regimens.

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The static prognostic risk factors noted in the present study are age above 40 years, presence of identifiable viral aetiology (A to E), alcoholic status in males and pregnancy particularly in the third trimester or postpartum state, among the dynamic factors.

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The aetiological agents responsible for, and the outcome of, acute liver failure were investigated prospectively in 44 children attending a tertiary health care facility in India between the ages of 2 months and 13 years.

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In 236 patients with fulminant viral hepatitis (FVH), type B (FBH) was most common (47.5%), followed by non‐A non‐B hepatitis (FNANB, 44.9%) and hepatitis type A (FAH, 7.6%). The survival rate was

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Most of patients with FHF might have been caused by hepatotropic viral infection, and non‐A, non‐B virus(es) seems to be the dominant hepatotropic Viral Viral infection among these patients.

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