Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension.

  title={Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension.},
  author={Jan E Carlsen and Troels Kardel and Jens Otto Lund and Alistair Mcnair and Jens Trap-Jensen},
  journal={Clinical pharmacology and therapeutics},
  volume={37 3},
In a double-blind, randomized, crossover study, the effects of intravenous pinacidil, 0.2 mg/kg, were compared with those of hydralazine, 0.3 mg/kg, before and after beta-adrenoceptor blockade in six subjects with hypertension. Both drugs equally reduced total peripheral resistance by about 40%. Pinacidil reduced mean blood pressure by an average of 30 mm Hg, while the reduction after hydralazine was 10 mm Hg. The difference in antihypertensive effect resulted from greater increases in heart… CONTINUE READING
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