Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction.

@article{Simon2016AcuteHE,
  title={Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction.},
  author={Marc A. Simon and Rebecca R Vanderpool and Mehdi S Nouraie and Timothy Bachman and Pamela M White and Masataka Sugahara and John Gorcsan and Ed L. Parsley and Mark T Gladwin},
  journal={JCI insight},
  year={2016},
  volume={1 18},
  pages={
          e89620
        }
}
BACKGROUND Pulmonary hypertension (PH) is associated with poor outcomes, yet specific treatments only exist for a small subset of patients. The most common form of PH is that associated with left heart disease (Group 2), for which there is no approved therapy. Nitrite has shown efficacy in preclinical animal models of Group 1 and 2 PH, as well as in patients with left heart failure with preserved ejection fraction (HFpEF). We evaluated the safety and efficacy of a potentially novel inhaled… CONTINUE READING