Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators.

@article{Slawsky2000AcuteHA,
  title={Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators.},
  author={Mara T. Slawsky and Wilson Steven Colucci and Stephen S Gottlieb and Barry H. Greenberg and Ernest Haeusslein and John Hare and Shaun Hutchins and Carl V. Leier and Thierry H Lejemtel and Evan Loh and John M. Nicklas and D. Ogilby and Bramah N. Singh and Wayne Smith},
  journal={Circulation},
  year={2000},
  volume={102 18},
  pages={2222-7}
}
BACKGROUND We determined the short-term hemodynamic and clinical effects of levosimendan, a novel calcium-sensitizing agent, in patients with decompensated heart failure. METHODS AND RESULTS One hundred forty-six patients with New York Heart Association functional class III or IV heart failure (mean left ventricular ejection fraction 21+/-1%) who had a pulmonary capillary wedge pressure >/=15 mm Hg and a cardiac index </=2.5 L x min(-1) x m(-2) were enrolled in a multicenter, double-blind… CONTINUE READING
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