Acute hematotoxicity of oral benzo(a)pyrene: the role of the Ah locus.

@article{Anselstetter1986AcuteHO,
  title={Acute hematotoxicity of oral benzo(a)pyrene: the role of the Ah locus.},
  author={Volker Anselstetter and Hermann Heimpel},
  journal={Acta haematologica},
  year={1986},
  volume={76 4},
  pages={217-23}
}
Our results show a marked acute hematotoxicity of oral benzo(a)pyrene (BaP) in D2 mice as well as the extreme resistance of BDF1 individuals to bone marrow toxicity induced by oral BaP. Continued oral BaP produced severe bone marrow depression in D2 mice affecting all myelopoietic lineages, but produced only moderate bone marrow depression in BDF1 mice… CONTINUE READING