Acute helminth infection enhances early macrophage mediated control of mycobacterial infection

@article{Plessis2013AcuteHI,
  title={Acute helminth infection enhances early macrophage mediated control of mycobacterial infection},
  author={Nicolette M. du Plessis and L{\'e}anie Kleynhans and Lani Thiart and Paul van Helden and Frank Brombacher and William G. C. Horsnell and Gerhard Walzl},
  journal={Mucosal Immunology},
  year={2013},
  volume={6},
  pages={931-941}
}
Co-infection with mycobacteria and helminths is widespread in developing countries, but how this alters host immunological control of each pathogen is not comprehensively understood. In this study, we demonstrate that acute Nippostrongylus brasiliensis (Nb) murine infection reduce early pulmonary mycobacterial colonization. This Nb-associated reduction in pulmonary Mycobacterium tuberculosis colony-forming units was associated with early and increased activation of pulmonary CD4 T cells and… CONTINUE READING