Acute haemodynamic and renal effects of cyclosporin and indomethacin in man.

@article{Sturrock1994AcuteHA,
  title={Acute haemodynamic and renal effects of cyclosporin and indomethacin in man.},
  author={N D Sturrock and Chim C Lang and Godfrey Clark and Allan D. Struthers},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1994},
  volume={9 8},
  pages={1149-56}
}
A single oral dose of cyclosporin (12 mg/kg) was given to healthy volunteers (n = 9) on day 2 with or without indomethacin pretreatment (100 mg day 1 + 100 mg day 2). All parameters reported were analysed after a water-loading protocol on day 2. As a peak drug effect within 4 h of drug ingestion on day 2 cyclosporin on its own increased mean arterial pressure by 13% (P < 0.05) without causing any sodium retention or renal vasoconstriction. Indomethacin pretreatment did not accentuate this… CONTINUE READING