Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome.

  title={Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome.},
  author={Antiopi Varelias and Kate L Ormerod and Mark D. Bunting and Motoko Koyama and Kate H Gartlan and Rachel D Kuns and Nancy Lachner and Kelly R. Locke and Chun Yong Lim and Andrea S Henden and Ping Zhang and Andrew D Clouston and Sumaira Z Hasnain and Michael A McGuckin and Bruce R Blazar and Kelli P A Macdonald and Philip Hugenholtz and Geoffrey R Hill},
  volume={129 15},
Donor T-cell-derived interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), however protective roles remain unclear. Using multiple cytokine and cytokine receptor subunit knockout mice, we demonstrate that stem cell transplant recipients lacking the ability to generate or signal IL-17 develop intestinal hyper-acute GVHD. This protective effect is restricted to the molecular interaction of IL-17A and/or IL-17F with the IL-17 receptor A/C (IL-17RA/C). The… CONTINUE READING
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