Acute graft-versus-host disease: are we close to bringing the bench to the bedside?

@article{Sung2013AcuteGD,
  title={Acute graft-versus-host disease: are we close to bringing the bench to the bedside?},
  author={Anthony D. Sung and Nelson J Chao},
  journal={Best practice & research. Clinical haematology},
  year={2013},
  volume={26 3},
  pages={285-92}
}
Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, activating T cells, resulting in proliferation and… CONTINUE READING