Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase.

@article{Wang1997AcuteGI,
  title={Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase.},
  author={Haiyan Wang and Patrick B. Iynedjian},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 41},
  pages={25731-6}
}
The INS-r3-GK27 insulinoma cells are endowed with artificially inducible glucokinase under control of the reverse tetracycline-dependent transcriptional activator. Moderate induction of glucokinase has been shown to result in proportionate increases in glycolytic flux and in potentiation of glucose effects on insulin secretion and pyruvate kinase gene… CONTINUE READING