Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses.

  title={Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses.},
  author={Timothy W Hand and Liliane Martins dos Santos and Nicolas Bouladoux and Michael J. Molloy and Antonio J. Pag{\'a}n and Marion Pepper and Craig L Maynard and Charles O Elson and Yasmine Belkaid},
  volume={337 6101},
The mammalian gastrointestinal tract contains a large and diverse population of commensal bacteria and is also one of the primary sites of exposure to pathogens. How the immune system perceives commensals in the context of mucosal infection is unclear. Here, we show that during a gastrointestinal infection, tolerance to commensals is lost, and microbiota-specific T cells are activated and differentiate to inflammatory effector cells. Furthermore, these T cells go on to form memory cells that… CONTINUE READING
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