Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses.

@article{Hand2012AcuteGI,
  title={Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses.},
  author={Timothy W Hand and Liliane Martins dos Santos and Nicolas Bouladoux and Michael J. Molloy and Antonio J. Pag{\'a}n and Marion Pepper and Craig L Maynard and Charles O Elson and Yasmine Belkaid},
  journal={Science},
  year={2012},
  volume={337 6101},
  pages={1553-6}
}
The mammalian gastrointestinal tract contains a large and diverse population of commensal bacteria and is also one of the primary sites of exposure to pathogens. How the immune system perceives commensals in the context of mucosal infection is unclear. Here, we show that during a gastrointestinal infection, tolerance to commensals is lost, and microbiota-specific T cells are activated and differentiate to inflammatory effector cells. Furthermore, these T cells go on to form memory cells that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 46 times over the past 90 days. VIEW TWEETS
107 Citations
32 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 107 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection

  • H. D. Marshall
  • Immunity 35,
  • 2011

Lochner et al . , Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th 17 cells

  • J. R. Oliver, A. J. Zajac, C. T. Weaver
  • 2011

Swiss HIV Cohort Study, Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection

  • A. Haas
  • Gut 60,
  • 2011

Similar Papers

Loading similar papers…