Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

@article{Comery2005AcuteGI,
  title={Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.},
  author={Thomas A. Comery and Robert L. Martone and Suzan B Aschmies and Kevin P Atchison and George Diamantidis and Xiaohai Gong and Hua Zhou and Anthony F. Kreft and Menelas N. Pangalos and June Sonnenberg-Reines and Janet S. Jacobsen and Karen L. Marquis},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 39},
  pages={8898-902}
}
Transgenic mice (Tg2576) overexpressing the Swedish mutation of the human amyloid precursor protein display biochemical, pathological, and behavioral markers consistent with many aspects of Alzheimer's disease, including impaired hippocampal function. Impaired, hippocampal-dependent, contextual fear conditioning (CFC) is observed in mice as young as 20 weeks of age. This impairment can be attenuated after treatment before training with the phosphodiesterase-4 inhibitor rolipram (0.1 mg/kg, i.p… CONTINUE READING

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