Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro.

@article{Vorberg2004AcuteFO,
  title={Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro.},
  author={Ina Vorberg and Anne Raines and Suzette A. Priola},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 28},
  pages={29218-25}
}
Transmissible spongiform encephalopathies are accompanied by the accumulation of a pathologic isoform of a host-encoded protein, termed prion protein (PrP). Despite the widespread distribution of the cellular isoform of PrP (protease-sensitive PrP; PrP-sen), the disease-associated isoform (protease-resistant PrP; PrP-res) appears to be primarily restricted to cells of the nervous and lymphoreticular systems. In order to study why scrapie infection appears to be restricted to certain cells, we… CONTINUE READING