Acute exposure to thyroid hormone increases Na+ current and intracellular Ca2+ in cat atrial myocytes.

@article{Wang2003AcuteET,
  title={Acute exposure to thyroid hormone increases Na+ current and intracellular Ca2+ in cat atrial myocytes.},
  author={Yong Gao Wang and Elena N. Dedkova and Jon P Fiening and Kaie Ojamaa and Lothar A Blatter and Stephen L. Lipsius},
  journal={The Journal of physiology},
  year={2003},
  volume={546 Pt 2},
  pages={491-9}
}
Whole-cell recording methods and fluorescence microscopy were used to study the effects of acute exposure to thyroid hormone (T(3)) on cat atrial myocytes. Acute exposure ( approximately 5 min) to 10 nM T(3) significantly increased tetrodotoxin (TTX)-sensitive inward Na(+) current (I(Na)) at voltages between -40 and +20 mV. At maximal I(Na) activation (-40 mV) T(3) increased peak I(Na) by 32 %. T(3) had no effect on the time course of I(Na) decay, voltage dependence of activation, inactivation… CONTINUE READING

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