Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.

  title={Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.},
  author={Daher Ibrahim Aibo and Neil Patrick Birmingham and Ryan P Lewandowski and Jane F. Maddox and Robert A. Roth and Patricia E. Ganey and James G. Wagner and Jack R. Harkema},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={115 1},
Ozone (O(3)), an oxidant air pollutant in photochemical smog, principally targets epithelial cells lining the respiratory tract. However, changes in gene expression have also been reported in livers of O(3)-exposed mice. The principal aim of the present study was to determine if acute exposure to environmentally relevant concentrations of O(3) could cause exacerbation of drug-induced liver injury in mice. Overdose with acetaminophen (APAP) is the most common cause of drug-induced liver injury… CONTINUE READING
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