Acute exposure to 3-methylcholanthrene induces hepatic oxidative stress via activation of the Nrf2/ARE signaling pathway in mice.

@article{Jin2014AcuteET,
  title={Acute exposure to 3-methylcholanthrene induces hepatic oxidative stress via activation of the Nrf2/ARE signaling pathway in mice.},
  author={Yuanxiang Jin and Wenyu Miao and Xiaojian Lin and Xiuhong Pan and Yang Ye and Minjie Xu and Zhengwei Fu},
  journal={Environmental toxicology},
  year={2014},
  volume={29 12},
  pages={
          1399-408
        }
}
  • Yuanxiang Jin, Wenyu Miao, +4 authors Zhengwei Fu
  • Published in Environmental toxicology 2014
  • Chemistry, Medicine
  • Polycyclic aromatic hydrocarbons (PAHs) are the most common contaminants in the environment. The primary focus on the toxicity of PAHs is their ability to activate the aryl hydrocarbon receptor (AhR)-mediated pathway and lead to carcinogenesis in different organisms. However, the influence of PAHs on the antioxidant system in mammalian systems has received only limited attention. In the present study, we observed that the intraperitoneal injection of 100 mg/kg 3-methylcholanthrene (3MC) into… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 13 CITATIONS

    Seasonal variations in fine particle composition from Beijing prompt oxidative stress response in mouse lung and liver.

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    CIA_A_237601 97..110

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Antioxidant Functions of the Aryl Hydrocarbon Receptor

    VIEW 1 EXCERPT
    CITES BACKGROUND

    NFAT5 protects astrocytes against oxygen–glucose–serum deprivation/restoration damage via the SIRT1/Nrf2 pathway

    VIEW 2 EXCERPTS
    CITES BACKGROUND