Acute exercise attenuates age-associated resistance to insulin-like growth factor I.

@article{Willis1997AcuteEA,
  title={Acute exercise attenuates age-associated resistance to insulin-like growth factor I.},
  author={Philippa E. Willis and Silia G. Chadan and Vickie Baracos and Wade Stephen Parkhouse},
  journal={The American journal of physiology},
  year={1997},
  volume={272 3 Pt 1},
  pages={
          E397-404
        }
}
This study examined the influence of acute exercise on the ability of insulin-like growth factor I (IGF-I) to stimulate protein synthesis in an isolated in vitro soleus muscle preparation in female C57Bl/6 mice aged 5, 12, and 24 mo. Gastrocnemius muscles were analyzed for IGF-I receptor mRNA levels, IGF-I receptor number, and IGF-I receptor binding capacities and affinity constants. IGF-I (20 nM) was unable to stimulate rates of protein synthesis in the 12- and 24-mo-old control animals. These… CONTINUE READING
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