Acute exacerbation during interferon alfa treatment of chronic hepatitis B: frequency and relation to serum β-2 microglobulin levels

@article{Akdoan2003AcuteED,
  title={Acute exacerbation during interferon alfa treatment of chronic hepatitis B: frequency and relation to serum β-2 microglobulin levels},
  author={M. Altan Akdoğan and Hakan Senturk and Ali Mert and Fehmi Tabak and Gulsen Ozbay},
  journal={Journal of Gastroenterology},
  year={2003},
  volume={38},
  pages={465-470}
}
Background. We aimed to determine the frequency of alanine aminotransferase (ALT) elevation during interferon-α treatment, the so-called “flare”, its relation to serum beta-2 microglobulin levels, and its impact on the outcome of treatment in chronic hepatitis B. Methods. The files of 53 treatment-naive patients with chronic hepatitis B (17 hepatitis B e antigen (HBeAg) +ve, 36 HBeAg −ve) who had been treated with 10 MU interferon-α 2b three times per week for 24 weeks were reviewed. We… CONTINUE READING
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