Acute ethanol responses in Drosophila are sexually dimorphic.

@article{Devineni2012AcuteER,
  title={Acute ethanol responses in Drosophila are sexually dimorphic.},
  author={Anita V. Devineni and Ulrike A Heberlein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 51},
  pages={21087-92}
}
In mammalian and insect models of ethanol intoxication, low doses of ethanol stimulate locomotor activity whereas high doses induce sedation. Sex differences in acute ethanol responses, which occur in humans, have not been characterized in Drosophila. In this study, we find that male flies show increased ethanol hyperactivity and greater resistance to ethanol sedation compared with females. We show that the sex determination gene transformer (tra) acts in the developing nervous system, likely… CONTINUE READING
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