Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes.

@article{Lu2015AcuteEI,
  title={Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes.},
  author={Xiao-yu Lu and Bingchen Liu and Lihua Wang and Li-li Yang and Qing Bao and Yu-jia Zhai and Abdel A Alli and T. Lidia Arockia Thai and Douglas C Eaton and Wei-zhi Wang and He-Ping Ma},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1853 5},
  pages={
          965-74
        }
}
  • Xiao-yu Lu, Bingchen Liu, +8 authors He-Ping Ma
  • Published 2015
  • Medicine, Biology
  • Biochimica et biophysica acta
  • Our recent studies indicate that hydrogen peroxide (H2O2) only at high concentrations can cause oxidative stress in renal epithelial cells and induce apoptosis of podocytes. Consistently, the present study shows that H2O2, even at 1 mM, failed to induce intracellular oxidative stress and apoptosis of the podocytes due to efficient activity of catalase, an enzyme which degrades H2O2 to produce water and oxygen (O2). However, H2O2 acted as a source of O2 to allow acute ethanol to induce… CONTINUE READING

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