Acute estradiol modulation of electrical activity of the LHRH pulse generator in the ovariectomized rat: restoration by naloxone.

@article{Kato1994AcuteEM,
  title={Acute estradiol modulation of electrical activity of the LHRH pulse generator in the ovariectomized rat: restoration by naloxone.},
  author={Akihiko Kawaguchil yoshihiro Kato and Hiromi Hiruma and Fukuko Kimura},
  journal={Neuroendocrinology},
  year={1994},
  volume={59 5},
  pages={426-31}
}
Whether estrogen has the brain as a site of its negative feedback action was investigated by checking the acute effect of estradiol-17 beta (E2) on the electrical activity of the luteinizing hormone-releasing hormone (LHRH) pulse generator in ovariectomized rats fitted with chronically implanted electrode arrays in the medial basal hypothalamus. Before subcutaneous E2 implantation, the hypothalamic multiunit activity (MUA) exhibited, at an average frequency of 2.43/h, characteristic increases… CONTINUE READING