Acute environmental hypoxia induces LC3 lipidation in a genotype-dependent manner.

@article{Masschelein2014AcuteEH,
  title={Acute environmental hypoxia induces LC3 lipidation in a genotype-dependent manner.},
  author={Evi Masschelein and Ruud van Thienen and Gommaar D'Hulst and Peter Hespel and Martine Thomis and Louise Deldicque},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 2},
  pages={1022-34}
}
Hypoxia-induced muscle wasting is a phenomenon often described with prolonged stays at high altitude, which has been attributed to altered protein metabolism. We hypothesized that acute normobaric hypoxia would induce a negative net protein balance by repressing anabolic and activating proteolytic signaling pathways at rest and postexercise and that those changes could be partially genetically determined. Eleven monozygotic twins participated in an experimental trial in normoxia and hypoxia (10… CONTINUE READING
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