Acute entry of bilirubin into rat brain regions.

In kernicterus bilirubin appears at higher concentrations in the basal ganglia, the cerebellum, and the medulla. The mechanism for this distribution is unknown, but might involve differences in bilirubin entry among brain regions. We infused [3H]bilirubin (30 mg/kg over 5 min) intravenously into young Sprague-Dawley rats (n = 21, weight 144 +/- 10 g, mean… CONTINUE READING