Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle.

  title={Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle.},
  author={Jonathan Peter Little and Adeel Safdar and Naomi M. Cermak and Mark Andrew Tarnopolsky and Martin J. Gibala},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={298 4},
  • J. LittleA. Safdar M. Gibala
  • Published 27 January 2010
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Peroxisome proliferator-activated receptor gamma coactivator (PGC-1alpha) is a transcriptional coactivator that plays a key role in coordinating mitochondrial biogenesis. Recent evidence has linked p38 MAPK and AMPK with activation of PGC-1alpha. It was recently shown in rodent skeletal muscle that acute endurance exercise causes a shift in the subcellular localization of PGC-1alpha from the cytosol to the nucleus, allowing PGC-1alpha to coactivate transcription factors and increase… 

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