Acute endothelinA receptor antagonism improves coronary artery compliance in coronary artery disease patients

@inproceedings{KyriakidesAcuteER,
  title={Acute endothelinA receptor antagonism improves coronary artery compliance in coronary artery disease patients},
  author={Zenon Kyriakides and Dimitrios Th. Kremastinos and Fotis Kolokathis and Anna G Kostopoulou and Michael Georgiadis and David J. Webb}
}
Endothelin (ET) exerts a tonic, stiffening effect on the common carotid artery in rats in vitro. This effect is mediated via the ETA receptor. The aim of this study was to examine the acute effects of ETA receptor antagonism on coronary artery compliance in humans. We examined 22 patients with stable angina after diagnostic coronary arteriography. Intracoronary BQ-123 (6 μmol), an ETA receptor antagonist (14 patients), or saline (8 patients), was infused in an artery without significant lesion… CONTINUE READING

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Endogenous endothelin type A receptor stimulation in patients undergoing coronary arteriography

  • Z. S. Kyriakides, Kremastinos, +4 authors D. J. Webb
  • Heart
  • 2000

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