Acute endothelin-1 application induces reversible fast axonal transport blockade in adult rat optic nerve.

@article{Wang2008AcuteEA,
  title={Acute endothelin-1 application induces reversible fast axonal transport blockade in adult rat optic nerve.},
  author={Xu Wang and William H Baldridge and Balwantray C Chauhan},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 3},
  pages={961-7}
}
PURPOSE To investigate the effects of endothelin (ET)-1 on fast axonal transport in the optic nerve. METHODS Sterile sponge soaked in 1 nM ET-1 was applied to the optic nerve surface of adult Brown Norway rats for 1 hour, after which 20% horseradish peroxidase (HRP) was placed over the superior colliculi (SC). Rats were killed 2, 4, 6, 24, and 48 hours later; the retinas and optic nerves were removed and fixed; and cut sections were processed histochemically, to visualize the time course of… CONTINUE READING