Acute elevation by short-term dietary restriction or food deprivation of type I I-compound levels in rat liver DNA.

@article{Zhou1999AcuteEB,
  title={Acute elevation by short-term dietary restriction or food deprivation of type I I-compound levels in rat liver DNA.},
  author={G. D. Zhou and Natalie Supunpong Hernandez and Erika Randerath and Kurt Randerath},
  journal={Nutrition and cancer},
  year={1999},
  volume={35 1},
  pages={87-95}
}
Type I I-compounds are bulky endogenous DNA modifications detectable by 32P postlabeling that exhibit age, species, tissue, genotype, gender, and diet dependence. Their formation appears unrelated to oxidative stress. In fact, several lines of indirect evidence suggest that many type I I-compounds may represent normal functional DNA modifications. For example, long-term dietary restriction (DR), which retards the development of age-related diseases including cancer and extends median and… CONTINUE READING

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