Acute efficacy of divalproex sodium versus placebo in mood stabilizer-naive bipolar I or II depression: a double-blind, randomized, placebo-controlled trial.

@article{Muzina2011AcuteEO,
  title={Acute efficacy of divalproex sodium versus placebo in mood stabilizer-naive bipolar I or II depression: a double-blind, randomized, placebo-controlled trial.},
  author={David J. Muzina and Keming Gao and David Eric Kemp and Sammy Khalife and Stephen J. Ganocy and Philip K S Chan and Mary Beth Serrano and Carla M Conroy and Joseph R. Calabrese},
  journal={The Journal of clinical psychiatry},
  year={2011},
  volume={72 6},
  pages={
          813-9
        }
}
OBJECTIVE To conduct an exploratory evaluation of the acute efficacy of extended-release divalproex sodium compared to placebo in patients with bipolar I or II depression. METHOD Outpatients aged 18-70 years with mood stabilizer-naive bipolar I or II disorder experiencing a major depressive episode (DSM-IV) were randomly assigned to 6 weeks of divalproex sodium monotherapy or placebo. The primary outcome measure was mean change from baseline to week 6 on the Montgomery-Åsberg Depression… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

A systematic review on the role of anticonvulsants in the treatment of acute bipolar depression.

The international journal of neuropsychopharmacology • 2013
View 5 Excerpts
Highly Influenced