Acute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use.


The extended-release formulation of zolpidem (Ambien CR) is approved for the treatment of insomnia without a treatment duration limit. Acutely zolpidem impairs performance, and no research to date has examined whether tolerance develops to these performance impairments during nighttime awakening. The present double-blind, placebo-controlled study examined… (More)
DOI: 10.1037/a0025237