Acute effects of tetrahydrobiopterin on the dynamic characteristics and adaptability of of vestibulo-ocular reflex in normal and flocculus lesioned rabbits.

@article{Nagao1997AcuteEO,
  title={Acute effects of tetrahydrobiopterin on the dynamic characteristics and adaptability of of vestibulo-ocular reflex in normal and flocculus lesioned rabbits.},
  author={Shoji Nagao and Hiromasa Kitazawa and Rhuichi Osanai and Takahito Hiramatsu},
  journal={Neuroscience letters},
  year={1997},
  volume={231 1},
  pages={41-4}
}
The acute effects of (6R)-5,6,7,8-tetrahydro-L-biopterin (R-THBP) on the dynamic characteristics of horizontal vestibulo-ocular reflex (HVOR) were examined in chronically prepared alert pigmented rabbits. The HVOR gain was measured by 10 degrees-0.1 Hz sinusoidal oscillation of the turntable in darkness. In control rabbits, intramuscular injection of R-THBP (10 mg/kg) induced an increase of HVOR gain by 0.1-0.2, which lasted for 1-3 h. Sustained 10 degrees-0.1 Hz sinusoidal oscillation of the… CONTINUE READING