Acute effects of testosterone infusion and naloxone on luteinizing hormone secretion in normal men.

@article{Kletter1992AcuteEO,
  title={Acute effects of testosterone infusion and naloxone on luteinizing hormone secretion in normal men.},
  author={Gad B. Kletter and Carol M. Foster and Inese Z. Beitins and John C. Marshall and Robert P. Kelch},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1992},
  volume={75 5},
  pages={
          1215-9
        }
}
To evaluate the role of endogenous opioid pathways in the acute suppression of LH secretion by testosterone (T) infusion in men, we studied eight normal healthy volunteers who received a saline infusion, followed 1 week later by a T infusion (960 nmol/h) starting at 1000 h and lasting for 33 h. After 2 h of infusion (both saline and T), four iv boluses of saline were given hourly, and after 26 h of infusion, four hourly iv boluses of naloxone were given. Blood was obtained every 15 min for LH… CONTINUE READING
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