Acute effects of nicotine on restraint stress-induced anxiety-like behavior, c-Fos expression, and corticosterone release in mice.

@article{Hsu2007AcuteEO,
  title={Acute effects of nicotine on restraint stress-induced anxiety-like behavior, c-Fos expression, and corticosterone release in mice.},
  author={Hui-Ru Hsu and Tsung-Yen Chen and Mun Hoe Eddy Chan and H. -H. Chen},
  journal={European journal of pharmacology},
  year={2007},
  volume={566 1-3},
  pages={
          124-31
        }
}
Clinical evidence suggests that nicotine reduces anxiety in stressful situations. In the present study, we investigated the effect of nicotine on restraint-enhanced anxiety-like behavior, c-Fos expression, an index of neuronal activation in the brain, and plasma corticosterone. Two-hour restraint stress-enhanced anxiety-like behavior in the elevated plus-maze (EPM) and nicotine hydrogen tartrate (0.25 mg/kg, i.p.) attenuated the stress-induced changes. Pretreatment with the centrally acting… CONTINUE READING
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