Acute effects of lorazepam on laboratory measures of aggressive and escape responses of adult male parolees

@article{Pietras2005AcuteEO,
  title={Acute effects of lorazepam on laboratory measures of aggressive and escape responses of adult male parolees},
  author={C. J. Pietras and Lori M Lieving and Don r. Cherek and Scott D. Lane and Oleg V. Tcheremissine and Sylvain O. Nouvion},
  journal={Behavioural Pharmacology},
  year={2005},
  volume={16},
  pages={243-251}
}
Acute benzodiazepine administrations typically decrease aggressive responding, but increases in aggression have been reported in some studies. The benzodiazepine lorazepam has been studied less frequently than other benzodiazepines in aggression research, although it is often used to suppress violent aggression in patients. The present study was designed to investigate the effects of acute administrations of lorazepam on aggressive responding in adult humans on a laboratory aggression task… 
Individual differences in aggressive responding to intravenous flumazenil administration in adult male parolees
TLDR
Investigation of the effects of acute administrations of flumazenil on aggressive responding in adult humans found that aggressive responses varied across subjects, and additional laboratory research is needed to better clarify the behavioural mechanisms by which BZD receptor antagonists modify human aggressive responding.
Effects of acute tiagabine administration on aggressive responses of adult male parolees
TLDR
A possible behavioral mechanism for the rate-decreasing effects on aggressive responding produced in the present study is that tiagabine may modify aggressive responding by suppressing reactions to aversive stimuli.
Growth hormone responses to GABAB receptor challenge with baclofen and impulsivity in healthy control and personality disorder subjects
TLDR
The magnitude of growth hormone response to baclofen, an index of GABAB receptor function, was negatively correlated with a dimensional measure impulsivity, but not related to the categorical diagnosis of personality disorder.
Human proactive aggression: association with personality disorders and psychopathy.
TLDR
The results suggest that proactive aggression may be identified in a laboratory-based task, and differences between proactive and reactive-only aggressors can be detected.
Benzodiazepine use and aggressive behaviour: A systematic review
TLDR
There appears to be a moderate association between some benzodiazepines and subsequent aggressive behaviour in humans, although some evidence suggests dose and/or personality factors may influence this effect.
Benzodiazepine-related aggression: consideration of intrapersonal factors
The thesis aimed to enhance understanding of the association between benzodiazepine use and subsequent aggression or violence. A systematic review and two original cross-sectional studies highlighted
Alcohol, Drugs, and Crime
There is a substantial body of research, beginning in the 1950s that supports an association between alcohol, drugs, and crime. Much of this research has focused specifically on violent crime.
A systematic review of prevention and intervention strategies for populations at high risk of engaging in violent behaviour: update 2002-8.
TLDR
This review was designed to examine the effectiveness of pharmacological, psychosocial and organisational interventions when they are developed in mental health and criminal justice populations, and to identify the key variables associated with a significant reduction in violence.
A systematic review of risk assessment strategies for populations at high risk of engaging in violent behaviour: update 2002-8.
TLDR
A very large number of studies examining the relationship between a structured instrument and a violent outcome were published in this relatively short 7-year period, and there is evidence of some convergence around a small number of high-performing instruments and identification of the components of a high-quality evaluation approach.
...
1
2
...

References

SHOWING 1-10 OF 56 REFERENCES
Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder
TLDR
Release of serotonin and/or reuptake blockade by d,l-fenfluramine is the possible mechanism for reductions in aggression and impulsivity, consistent with a large body of data linking reduced serotonin function and aggressive behavior and impulsiveness.
Effects of acute administration of diazepam andd-amphetamine on aggressive and escape responding of normal male subjects
TLDR
Normal males participated in sessions providing two operant response options and were administered either diazepam (study I and II) ord-amphetamine (study II) to determine the extent to which social context and response consequence influenceddiazepam andd-amphetamine effects on aggressive responding.
Effects of clorazepate, diazepam, and oxazepam on a laboratory measurement of aggression in men
TLDR
Results support the notion that diazepam (but not all benzodiazepines) can elicit aggressive behavior under controlled, laboratory conditions and implications regarding the clinical use of various Benzodiazepine for the tranquilization of potentially assaultive patients are discussed.
Differential effects of oxazepam and lorazepam on aggressive responding
TLDR
Two doses of two very similar benzodiazepines had very similar subjective effects, but the higher dose of lorazepam increased aggressive responding on the task more than any other treatment, which may be related to the different ceiling efficacies of the two benzodiazines.
Quantitative and comparative analyses of pro-aggressive actions of benzodiazepines in maternal aggression of rats
TLDR
A comparison of the drug effects on different aggressive elements revealed that chlordiazepoxide and oxazepam increased the frequency of more elements of the aggressive repertoire than diazepam or alprazolam.
Differential effects of six structurally related benzodiazepines on some ethological measures of timidity, aggression and locomotion in mice
TLDR
The present study suggests that 2′ deschloro-phenyl-benzodiazepines are less “sedative” with respect to their “anxiolytic” activity.
Parenteral lorazepam versus parenteral haloperidol for the control of psychotic disruptive behavior.
TLDR
Data support the current clinical practice of using lorazepam (alone, or in combination with a neuroleptic) for control of acute aggressive and assaultive behavior.
Effect of various psychotropic drugs on the performance of avoidance and escape behaviors in rats
  • R. Rodríguez
  • Psychology
    Pharmacology Biochemistry and Behavior
  • 1992
The GABAergic effect of low doses of lorazepam on social behavior
TLDR
The aim of this work was to test the antiaggressive effects of lorazepam and to determine whether these effects were mediated by benzodiazepine receptors and whether Ro 15-1788 was successful in completely antagonizing the behavior modulated by lorzepam.
...
1
2
3
4
5
...