Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

@article{Hill2008AcuteEO,
  title={Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.},
  author={Jennifer W. Hill and Kevin W. Williams and Chianping Ye and Ji Luo and Nina Balthasar and Roberto Coppari and Michael Alexander Cowley and Lewis C. Cantley and Bradford B. Lowell and Joel K Elmquist},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 5},
  pages={1796-805}
}
Normal food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed that leptin action requires PI3K activity. We therefore assessed the contribution of PI3K signaling to leptin's effects on POMC neurons and organismal energy balance. Leptin caused a rapid depolarization of POMC neurons and an increase in action potential frequency in patch-clamp recordings of hypothalamic slices. Pharmacologic inhibition of… CONTINUE READING
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