Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.


Normal food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed that leptin action requires PI3K activity. We therefore assessed the contribution of PI3K signaling to leptin's effects on POMC neurons and organismal energy balance. Leptin caused a rapid depolarization… (More)
DOI: 10.1172/JCI32964


9 Figures and Tables