Acute effects of cyclosporin and cremophor EL on endothelial function and vascular smooth muscle in the isolated rat heart

Abstract

We studied the effects of cyclosporin dissolved in the vehicle used as an intravenous preparation, namely, cremophor EL, and cremophor alone on the basal coronary flow plus endothelial function and vascular smooth muscle response by examining their influence on 5-hydroxytryptamine (5-HT) and nitroglycerine (GTN) induced changes in coronary flow in the… (More)
DOI: 10.1007/BF00050920

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@article{Mankad1992AcuteEO, title={Acute effects of cyclosporin and cremophor EL on endothelial function and vascular smooth muscle in the isolated rat heart}, author={Pankaj S Mankad and Jaroslav {\vS}patenka and Zdeněk Slav{\'i}k and Gregory O'Neil and Adrian H Chester and Prof Magdi Yacoub}, journal={Cardiovascular Drugs and Therapy}, year={1992}, volume={6}, pages={77-83} }