Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria.

@article{CunhaOliveira2013AcuteEO,
  title={Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria.},
  author={Teresa Cunha-Oliveira and Lisbeth Silva and Ana Maria Sin{\'i}cio da Silva and Ant{\'o}nio J. M. Moreno and Catarina Resende de Oliveira and Maria Santos},
  journal={Life sciences},
  year={2013},
  volume={92 24-26},
  pages={1157-64}
}
AIMS Cocaine and heroin are frequently co-abused in a combination known as speedball. Despite the relevance of the liver in the metabolism and detoxification of these drugs, little is known about the impact of speedball on liver function. MAIN METHODS In this work, we evaluated the effects of cocaine, morphine and morphine+cocaine (Mor+Coc) combination (1:1) in isolated rat liver mitochondria, upon glutamate/malate or succinate energization, on bioenergetics and oxidative stress-related… CONTINUE READING

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