Acute effects of MK801 on kainic acid-induced seizures in neonatal rats

@article{Stafstrom1997AcuteEO,
  title={Acute effects of MK801 on kainic acid-induced seizures in neonatal rats},
  author={Carl E Stafstrom and Pushpa Tandon and Ariyuki Hori and Zhao Liu and Gregory L. Holmes},
  journal={Epilepsy Research},
  year={1997},
  volume={26},
  pages={335-344}
}
Kainic acid (KA) causes behavioral and electrographic status epilepticus (SE) in rats of all ages. In adult rats, the noncompetitive N-methyl-D-aspartate (NMDA) channel blocker MK801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine ) is anticonvulsant against KA-induced seizures: it reduces their severity and protects against neuronal damage, although it may worsen electrographic seizures. Here we examined the effects of MK801 on KA seizures in the immature brain. Neonatal… CONTINUE READING

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